Estimating the extent of the health hazard posed by high-production volume chemicals. | Zendy

Albert R. Cunningham | Zendy; H S Rosenkranz | Zendy

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Estimating the extent of the health hazard posed by high-production volume chemicals.

Author(s) -

Albert R. Cunningham,

H S Rosenkranz

Publication year - 2001

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.01109953

Subject(s) - genotoxicity , toxicology , environmental health , carcinogen , environmental science , toxicity , environmental chemistry , biology , chemistry , medicine , genetics

We used structure-activity relationship modeling to estimate the number of toxic chemicals among the high-production volume (HPV) group. We selected 200 chemicals from among the HPV chemical list and predicted the potential of each for its ability to induce a variety of adverse effects including genotoxicity, carcinogenicity, developmental, and systemic toxicity. We found a significantly less than expected proportion of toxic chemicals among the HPV sample when compared to a reference set of 10,000 chemicals representative of the universe of chemicals.

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