Calculating bone-lead measurement variance. | Zendy

Andrew C. Todd | Zendy

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Calculating bone-lead measurement variance.

Author(s) -

Andrew C. Todd

Publication year - 2000

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.1289/ehp.00108383

Subject(s) - observational error , variance (accounting) , calibration , covariance , reproducibility , statistics , lead (geology) , accuracy and precision , computer science , mathematics , environmental science , geology , accounting , business , geomorphology

The technique of (109)Cd-based X-ray fluorescence (XRF) measurements of lead in bone is well established. A paper by some XRF researchers [Gordon CL, et al. The Reproducibility of (109)Cd-based X-ray Fluorescence Measurements of Bone Lead. Environ Health Perspect 102:690-694 (1994)] presented the currently practiced method for calculating the variance of an in vivo measurement once a calibration line has been established. This paper corrects typographical errors in the method published by those authors; presents a crude estimate of the measurement error that can be acquired without computational peak fitting programs; and draws attention to the measurement error attributable to covariance, an important feature in the construct of the currently accepted method that is flawed under certain circumstances.

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