Curative Effect of Bone Marrow Cells Transplantation and/or Low Dose Gamma Irradiation on Liver Injuries Induced by Carbon Tetrachloride

Liver is the most common target for toxic injury. Toxic agents include chemicals such as carbon tetrachloride (CCl4) and trichloroethylene. This study aimed to evaluate the effect of bone marrow cells (BMC) transplantation and/or fractionated low doses (0.5 Gy) gamma radiation on established liver fibrosis induced by CCl4. BMCs of male albino rats were transplanted into 4-weeks carbon tetrachloride (CCl4)–treated and/or fractionated low doses (0.5 Gy) gamma irradiated rats through the tail vein, and the rats were treated for 4 more weeks with CCl4 (total 8 weeks). Histological and ultrastructural investigations revealed that both bone marrow cells transplantation and low dose (0.5 Gy) gamma radiation exposure with continuous CCl4 injection had reduced liver fibrosis as compared with rats treated with CCl4 alone.