Determination of Cyanide in Biological and Non - Biological Matrices by Headspace Gas Chromatography Coupled to Flame - Ionization Detector | Zendy

Humera Shafi | Zendy; Adeel Subhani | Zendy; Muhammad Imran | Zendy

Open Access

Determination of Cyanide in Biological and Non - Biological Matrices by Headspace Gas Chromatography Coupled to Flame - Ionization Detector

Author(s) -

Humera Shafi,

Adeel Subhani,

Muhammad Imran

Publication year - 2015

Publication title -

arab journal of forensic sciences and forensic medicine

Language(s) - English

Resource type - Journals

eISSN - 1658-6794

pISSN - 1658-6786

DOI - 10.12816/0011256

Subject(s) - flame ionization detector , gas chromatography , chromatography , detector , chemistry , cyanide , ionization , analytical chemistry (journal) , physics , organic chemistry , optics , ion

A simple, rapid and reliable method for quantitation of cyanide was developed on a headspace gas chromatograph coupled to a flame ionization detector using a HP-Innovax (Polyethylene glycol bonded) column on an Agilent 7890A GC. Cyanide in blood or other matrices was liberated by conversion of potassium cyanide to the volatile hydrogen cyanide (HCN) through addition of 5N sulfuric acid in a headspace vial and analyzed using an Agilent G1888 headspace auto-sampler. HCN gas diffuses into the headspace above the specimen in a sealed vial based on Henry’s Law of partial pressure.

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