Primary giant cell tumor of soft tissue on mandibular region: a case report and literature review

Primary giant cell tumor of the soft tissue was first defined by Salm and Sissons as a tumoral lesion histologically identical to the giant cell tumor of the bone and clinically benign even though having some local recurrences. However, subsequent studies have demonstrated that besides benign forms, tumor also had potentially malignant and malignant forms. In this case, we evaluated a tumor seen on a woman at 27 years old and rare in location (mandibular region) and diagnosed as 'primary giant cell tumor of the soft tissue' (PGCT-ST). We also impressed on the differential diagnosis of the case by evaluating the morphological and immunohistochemical properties of the tumor. Moreover, since potentially malignant and malignant forms of the tumor were also defined, we reviewed the criteria of differential diagnosis and the literature again and tried to make the clinical behavior of the tumor clear. Keywords: Low grade giant cell tumor, soft tissue, mandibular region Ozet Yumusak dokularin primer dev hucreli tumoru ilk olarak Salm ve Sissons tarafindan histolojik olarak kemigin dev hucreli tumorune benzer ve klinik olarak bazi lokal rekurrensleri olsa da benign bir lezyon olarak tanimlanmistir; ama daha sonraki calismalar benign formlarin yaninda tumorun potansiyel olarak malign veya malign formlarinin oldugunu gostermistir. Bu olguda 27 yasinda bir kadinda ve mandibuler bolge gibi nadir bir yerde saptanan yumusak dokunun primer dev hucreli tumoru olarak tanimlanan bir tumor sunulmustur. Bu olgu dolayisi ile bu tumorlerin morfolojik ve immunohistopatolojik ozellikleri ele alinmistir. Bu yaklasimla tumorun ayirici tanisi literatur esliginde ele alinarak tumorun klinik ozelliklerinin aciklanmasina calisilmistir. Anahtar Sozcukler: Dusuk dereceli dev hucreli tumor, yumusak doku, mandibular bolge