Open AccessWhy Biologic Therapies Sometimes Lose Efficacy
Author(s) -
Bruce Strober
Publication year - 2016
Publication title -
seminars in cutaneous medicine and surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.66
H-Index - 64
eISSN - 1558-0768
pISSN - 1085-5629
DOI - 10.12788/j.sder.2016.022
Subject(s) - medicine , immunogenicity , dosing , psoriasis , intensive care medicine , drug , pharmacology , immunology , immune system
Biologic therapies for psoriasis are associated with loss of response over time. Immunogenicity, suboptimal dosing, low serum drug levels, and intermittent or episodic therapy have been documented as explanations for this phenomenon. Use of an immunomodulatory agent can reduce the risk of immunogenicity and improve clinical response.
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