Relationships between changes in entropy of the EEG and parameters of the immunity

Background. Previously, we have shown that the entropy of the normalized parameters of the HRV and spectral power density (SPD) of loci of EEG significantly correlate with the entropy and parameters of immunity, which testifies to their modulating regulatory effects. The purpose of this study is to analyze the relationships between changes in entropy and immunity under the influence of natural adaptogens. Material and methods. In basal conditions in 37 men and 14 women with chronic pyelonephritis and cholecystitis in remission as well as without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). Than we evaluated immune status on a set of I and II levels recommended by the WHO. The Entropy of normalized SPD for each locus of EEG and HRV as well as Immunocytogram and Leukocytogram calculated using Shannon’s formula. Results. Preliminary analysis revealed different orientation of entropy changes in patients, so three clusters were created. Balneotherapy has a generalized negentropic effect on EEG of 2/3 patients. On the other hand, the members of the other two clusters have substantially increased EEG entropy overall, but there are significant differences with respect to individual loci. The immunotropic effects of balneotherapy are unrelated to changes in integral entropy of EEG. As a result of discriminant analysis were selected as characteristic entropy changes at only 9 loci out of 16, accompanied by changes in 10 partial parameters of immunity and integral immune index, as well as Popovych’s Leukocytogram Strain Index-2. Conclusion. Balneotherapy causes multivariate entropy changes of individual EEG loci, conditioned by a number of predictors. This is accompanied by characteristic changes in certain parameters of immunity in line with the concept of immune homunculus.