Towards better non-selectivity: the role of 5-HT7 receptors in therapeutic efficacy of a second-generation antipsychotic, lurasidone | Zendy

Przemysław Bieńkowski | Zendy; Dominika Dudek | Zendy; Jerzy Samochowiec | Zendy

Open Access

Towards better non-selectivity: the role of 5-HT7 receptors in therapeutic efficacy of a second-generation antipsychotic, lurasidone

Author(s) -

Przemysław Bieńkowski,

Dominika Dudek,

Jerzy Samochowiec

Publication year - 2015

Publication title -

psychiatria polska

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.414

H-Index - 22

eISSN - 2391-5854

pISSN - 0033-2674

DOI - 10.12740/pp/38250

Subject(s) - lurasidone , antipsychotic , receptor , pharmacology , medicine , schizophrenia (object oriented programming) , psychiatry

Effectiveness of currently available antipsychotic medications is far from satisfactory with many patients showing incomplete therapeutic response even after many trials with different antipsychotic drugs. Hence, there is an ongoing interest in searching for pharmacological mechanisms, which could potentiate therapeutic response to antipsychotic drugs and/or reduce its typical side effects. The primary aim of this mini-review is to summarize available evidence supporting the role of serotonin receptors, especially 5-HT7 receptors, in therapeutic effects of a second-generation antipsychotic drug, lurasidone.

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