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Unilateral ovariectomy (UOE) of female rats caused an increase in duration of the non­reproductive period (NRP) – metestrus and diestrus phases, and shortening of the reproductive period (RP) – proestrus and estrus phases of the estrous cycle (a symptom of hormonal deficiency). Signs of stress persisted 5 weeks after UOE: reduction of the ratio of thymus weight to the weight of adrenal glands (T/A). A two­week course of the succinate­containing composition with added B vitamins (SCCV) administered to the control female rats and those upon UOE has increased the T/A ratio as compared to that of intact animals, which is an indication of “activation” according to Garkavi et al. [1] and restored the NRP/RP ratio. Cytobiochemical analysis found a significant increase in nitroblue tetrazolium reduction during succinate oxidation in lymphocytes according to reading of animal blood smears.

Correction of the functional state of female rats after unilateral ovariectomy using a succinate containing composition