Neurophysiological status and adaptation responses upon application of electromagnetic fields in complex treatment of patients with malignant gliomas of the brain

Materials and methods Our examination focused on patients suffering from malignant gliomas of the brain. One cohort of them (the reference group covering 30 patients) received surgery and chemoradiotherapy (CHRT) without electromagnetic field exposure of the brain, while the other group (the main test group which included 30 individuals) was subjected to the same therapy, but accompanied by the electromagnetic field treatment of the brain. Varying and permanent magnetic field exposure sessions were carried out from day 1 till day 20 in the context of the complex therapy. All in all, every patient received 4 courses of the systemic chemotherapy, with an interruption of 4 weeks, in combination with exposures to electromagnetic field applied to the brain area. An assessment of efficacy of the adjuvant chemoradiotherapy was performed upon expiration of 12-14 days from the date of the last injection of chemotherapy drugs according to applicable WHO recommendations for standardizing in assessment of treatment outcomes.