Occurrence of HLA- and Non-HLA Antibodies after Heart Transplantation are Associated with Cardiac Allograft Vasculopathy | Zendy

Markus J. Barten | Zendy; MajaTheresa Dieterlen | Zendy; Jens Garbade | Zendy; Robert Riede | Zendy; Stefan Dhein | Zendy; Friedrich W. Mohr | Zendy; Hartmuth B. Bittner | Zendy

Open Access

Occurrence of HLA- and Non-HLA Antibodies after Heart Transplantation are Associated with Cardiac Allograft Vasculopathy

Author(s) -

Markus J. Barten,

MajaTheresa Dieterlen,

Jens Garbade,

Robert Riede,

Stefan Dhein,

Friedrich W. Mohr,

Hartmuth B. Bittner

Publication year - 2014

Publication title -

cardiometry

Language(s) - English

Resource type - Journals

ISSN - 2304-7232

DOI - 10.12710/cardiometry.2014.4.7185

Subject(s) - cardiac allograft vasculopathy , medicine , human leukocyte antigen , heart transplantation , transplantation , antibody , cardiology , immunology , antigen

Materials and methods Sera of 116 long-term HTx recipients with CAV (n=46) and without CAV (n=70) were analysed by (1) Luminex for Abs against both HLA classes and major histocompatibility complex class I-related chain A (MICA), and by (2) ELISA for Abs against angiotensin-type-1-receptor (AT1R) or endothelin-receptor-A (ETAR). Cellular rejection by endomyocardial biopsies and immunosuppressive drug therapy were analysed, too.

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