Open AccessSynthesis of γ-Lactone-Type Sialic Acid, an Isomer of 2,3-Dehydrosialic Acid
Author(s) -
Yoshiharu Sawada,
Shinichi Nakatsuka
Publication year - 2010
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.90912
Subject(s) - lactone , sialic acid , chemistry , yield (engineering) , ether , stereochemistry , organic chemistry , biochemistry , materials science , metallurgy
An efficient synthesis of gamma-lactone-type sialic acid, which is an isomer of 2,3-dehydrosialic acid, was achieved from the corresponding sialic ester. The sialic ester was reconstructed from the gamma-lactone in a 95% yield. The gamma-lactone structure was determined by methylating to its corresponding methyl ether.
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