In Vitroandin VivoEvaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection | Zendy

Mizuho Inagaki | Zendy; Mayumi Yamamoto | Zendy; Xijier | Zendy; Cairangzhuoma | Zendy; Kenji Uchida | Zendy; Hiroshi Yamaguchi | Zendy; Mihoko Kawasaki | Zendy; K Yamashita | Zendy; Tomio Yabe | Zendy; Yoshihiro Kanamaru | Zendy

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In Vitroandin VivoEvaluation of the Efficacy of Bovine Colostrum against Human Rotavirus Infection

Author(s) -

Mizuho Inagaki,

Mayumi Yamamoto,

Xijier,

Cairangzhuoma,

Kenji Uchida,

Hiroshi Yamaguchi,

Mihoko Kawasaki,

K Yamashita,

Tomio Yabe,

Yoshihiro Kanamaru

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90862

Subject(s) - colostrum , in vivo , rotavirus , potency , in vitro , diarrhea , inoculation , virology , biology , microbiology and biotechnology , virus , immunology , medicine , antibody , biochemistry

We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.

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