Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications | Zendy

Takeshi Ishii | Zendy; Mitsugu Akagawa | Zendy; Yuji Naito | Zendy; Osamu Handa | Zendy; Tomohisa Takagi | Zendy; Taiki Mori | Zendy; Shigenori Kumazawa | Zendy; Toshikazu Yoshikawa | Zendy; Tsutomu Nakayama | Zendy

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Pro-Oxidant Action of Pyrroloquinoline Quinone: Characterization of Protein Oxidative Modifications

Author(s) -

Takeshi Ishii,

Mitsugu Akagawa,

Yuji Naito,

Osamu Handa,

Tomohisa Takagi,

Taiki Mori,

Shigenori Kumazawa,

Toshikazu Yoshikawa,

Tsutomu Nakayama

Publication year - 2010

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90764

Subject(s) - pyrroloquinoline quinone , quinone , oxidative phosphorylation , redox , chemistry , biochemistry , intracellular , peptide , enzyme , cofactor , organic chemistry

Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.

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