Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes | Zendy

Satoko Akiyama | Zendy; Shin-ichi Katsumata | Zendy; Kazuharu Suzuki | Zendy; Yumi Nakaya | Zendy; Yoshiko Ishimi | Zendy; Mariko Uehara | Zendy

Open Access

Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes

Author(s) -

Satoko Akiyama,

Shin-ichi Katsumata,

Kazuharu Suzuki,

Yumi Nakaya,

Yoshiko Ishimi,

Mariko Uehara

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90576

Subject(s) - hesperetin , hesperidin , chemistry , pharmacology , type 2 diabetes , endocrinology , biochemistry , diabetes mellitus , medicine , flavonoid , antioxidant , alternative medicine , pathology

We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.

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