Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase | Zendy

Florin Barla | Zendy; Hayato HIGASHIJIMA | Zendy; Shingo FUNAI | Zendy; Keiichiro Sugimoto | Zendy; Naoki Harada | Zendy; Ryoichi Yamaji | Zendy; Tomoyuki Fujita | Zendy; Yoshihisa Nakano | Zendy; Hiroshi Inui | Zendy

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Inhibitive Effects of Alkyl Gallates on Hyaluronidase and Collagenase

Author(s) -

Florin Barla,

Hayato HIGASHIJIMA,

Shingo FUNAI,

Keiichiro Sugimoto,

Naoki Harada,

Ryoichi Yamaji,

Tomoyuki Fujita,

Yoshihisa Nakano,

Hiroshi Inui

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90365

Subject(s) - hyaluronidase , collagenase , propyl gallate , chemistry , gallate , enzyme , biochemistry , nuclear chemistry , antioxidant

A series of the gallate esters of n-alkanols (C(1)-C(12)) was examined to determine their inhibitory activities against hyaluronidase and collagenase. Hexyl, heptyl, octyl, nonyl, and decyl gallates inhibited both hyaluronidase and collagenase, and the most potent inhibitor was octyl gallate against both enzymes. Octyl 3,5-dihydroxybenzoate showed inhibitory effects on hyaluronidase, whereas collagenase was inhibited by octyl 3,4-dihydroxybenzoate.

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