Open AccessEnantioselective Synthesis of Aspergillide B
Author(s) -
Tomohiro Nagasawa,
Shigefumi Kuwahara
Publication year - 2009
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.90221
Subject(s) - enantioselective synthesis , yield (engineering) , stereochemistry , chemistry , combinatorial chemistry , organic chemistry , materials science , catalysis , metallurgy
The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.
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