Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats | Zendy

Mamoru Tanida | Zendy; Nobuo Tsuruoka | Zendy; Jiao Shen | Zendy; Yuko Horii | Zendy; Yoshinori Beppu | Zendy; Yoshinobu Kiso | Zendy; Katsuya Nagai | Zendy

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Effects of Flavangenol on Autonomic Nerve Activities and Dietary Body Weight Gain in Rats

Author(s) -

Mamoru Tanida,

Nobuo Tsuruoka,

Jiao Shen,

Yuko Horii,

Yoshinori Beppu,

Yoshinobu Kiso,

Katsuya Nagai

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90196

Subject(s) - brown adipose tissue , endocrinology , medicine , adipose tissue , vagus nerve , body weight , neurotransmission , autonomic nervous system , weight gain , autonomic nerve , heart rate , receptor , blood pressure , stimulation

In a previous report, evidence was presented that flavangenol supplementation has an anti-ischemic effects in rats. In the study presented here, we examined the autonomic effects of intraduodenal (ID) injection of flavangenol in urethane-anesthetized rats and found that it increased sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) in a dose-dependent manner, while it suppressed gastric vagal nerve activity (GVNA). In addition, intra-oral (IO) injection of flavangenol elevated brown adipose tissue temperature (BAT-T). Furthermore, flavangenol drinking for 15 d reduced body weight gain in rats fed a high-fat diet. These results thus suggest that flavangenol supplementation exerts its reducing action on body weight through changes in autonomic neurotransmission.

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