Pinostrobin fromBoesenbergia pandurataIs an Inhibitor of Ca2+-Signal-Mediated Cell-Cycle Regulation in the YeastSaccharomyces cerevisiae | Zendy

Wachirasak Wangkangwan | Zendy; Saipin Boonkerd | Zendy; Warinthorn Chavasiri | Zendy; Kasama Sukapirom | Zendy; Kovit Pattanapanyasat | Zendy; Ngampong Kongkathip | Zendy; Tokichi Miyakawa | Zendy; Chulee Yompakdee | Zendy

Open Access

Pinostrobin fromBoesenbergia pandurataIs an Inhibitor of Ca²⁺-Signal-Mediated Cell-Cycle Regulation in the YeastSaccharomyces cerevisiae

Author(s) -

Wachirasak Wangkangwan,

Saipin Boonkerd,

Warinthorn Chavasiri,

Kasama Sukapirom,

Kovit Pattanapanyasat,

Ngampong Kongkathip,

Tokichi Miyakawa,

Chulee Yompakdee

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90114

Subject(s) - pinocembrin , saccharomyces cerevisiae , yeast , rhizome , chalcone , biochemistry , chemistry , signal transduction , biology , stereochemistry , flavonoid , botany , antioxidant

Upon searching plant extracts for inhibitors of the Ca(2+) signaling pathway using the zds1Delta-yeast proliferation based assay, a crude rhizome extract of Boesenbergia pandurata was found to be strongly positive, and from this extract pinostrobin, alpinetin, and pinocembrin chalcone were isolated as active components. Further biochemical experiments confirmed that pinostrobin possesses inhibitory activity on the Ca(2+) signals involved in the control of G2/M phase cell cycle progression in Saccharomyces cerevisiae.

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