Effective Synthesis of Optically Active Trifluoromethyldiazirinyl Homophenylalanine and Aroylalanine Derivatives with the Friedel-Crafts Reaction in Triflic Acid | Zendy

Ryo Murashige | Zendy; Yuta Murai | Zendy; Yasumaru Hatanaka | Zendy; Makoto Hashimoto | Zendy

Open Access

Effective Synthesis of Optically Active Trifluoromethyldiazirinyl Homophenylalanine and Aroylalanine Derivatives with the Friedel-Crafts Reaction in Triflic Acid

Author(s) -

Ryo Murashige,

Yuta Murai,

Yasumaru Hatanaka,

Makoto Hashimoto

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.90027

Subject(s) - triflic acid , optically active , friedel–crafts reaction , chemistry , trifluoromethyl , trifluoromethylation , diazirine , organic chemistry , combinatorial chemistry , catalysis , stereochemistry , alkyl

The Friedel-Crafts reaction with 3-(3-methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine and optically active N-TFA-Asp(Cl)-OMe in triflic acid afforded homophenylalanine derivatives without any loss of the optical purity.

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