Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells | Zendy

Y. Yamaoka | Zendy; Kenji Ohguchi | Zendy; Tomohiro Itoh | Zendy; Yoshinori Nozawa | Zendy; Yukihiro Akao | Zendy

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Effects of Theaflavins on Melanin Biosynthesis in Mouse B16 Melanoma Cells

Author(s) -

Y. Yamaoka,

Kenji Ohguchi,

Tomohiro Itoh,

Yoshinori Nozawa,

Yukihiro Akao

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80880

Subject(s) - theaflavin , tyrosinase , melanin , melanoma , inhibitory postsynaptic potential , polyphenol , chemistry , melanocyte , pharmacology , endocrinology , biochemistry , biology , cancer research , enzyme , antioxidant

In this study, we examined the effects of theaflavins, polyphenols in black tea, on alpha melanocyte-stimulating hormone (alphaMSH)-induced melanogenesis in mouse B16 melanoma cells. Among theaflavins, theaflavin-3,3'-digallate (TF-3) exhibited a potent inhibitory effect on melanogenesis. Our results indicate that the inhibitory effect of TF-3 on melanogenesis is due to suppression of tyrosinase protein and mRNA levels.

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