The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity | Zendy

Yumi Kidachi | Zendy; Toshiro Noshita | Zendy; Hideaki Yamaguchi | Zendy; Hironori Umetsu | Zendy; Yoko Fuke | Zendy; Kazuo Ryoyama | Zendy

Open Access

The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity

Author(s) -

Yumi Kidachi,

Toshiro Noshita,

Hideaki Yamaguchi,

Hironori Umetsu,

Yoko Fuke,

Kazuo Ryoyama

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80791

Subject(s) - thiol , glutathione , isothiocyanate , chemistry , cytotoxic t cell , biological activity , cytotoxicity , biochemistry , enzyme , in vitro

We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.

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