Effect of White Wheat Bread Containing Sugar Beet Fiber on Serum Lipids and Hepatic mRNA in Rats Fed on a Cholesterol-Free Diet | Zendy

Yumi Nakamura | Zendy; Mizuki Kanazawa | Zendy; Ruvini Liyanage | Zendy; Setsuko Iijima | Zendy; KyuHo Han | Zendy; Kenichiro Shimada | Zendy; Mitsuo Sekikawa | Zendy; Akihiro Yamauchi | Zendy; Naoto Hashimoto | Zendy; Kiyoshi Ohba | Zendy; Michihiro Fukushima | Zendy

Open Access

Effect of White Wheat Bread Containing Sugar Beet Fiber on Serum Lipids and Hepatic mRNA in Rats Fed on a Cholesterol-Free Diet

Author(s) -

Yumi Nakamura,

Mizuki Kanazawa,

Ruvini Liyanage,

Setsuko Iijima,

KyuHo Han,

Kenichiro Shimada,

Mitsuo Sekikawa,

Akihiro Yamauchi,

Naoto Hashimoto,

Kiyoshi Ohba,

Michihiro Fukushima

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80787

Subject(s) - cholesterol 7 alpha hydroxylase , cholesterol , sugar beet , feces , chemistry , bile acid , blood lipids , food science , excretion , biology , medicine , biochemistry , agronomy , paleontology

We examined the effects of white wheat bread powder (BP) and white wheat bread powder containing sugar beet fiber (BBP) on serum cholesterol. The total cholesterol (-11%, -16%), HDL-cholesterol (-12%, -11%), non-HDL-cholesterol (-9%, -18%) and triacylglycerol (-44%, -58%) concentrations in the BP and BBP groups, respectively, were significantly different from those in the control group. The fecal excretion of neutral sterols in the BP and BBP groups and of acidic sterols in the BBP group was significantly higher than that in the control group. The hepatic cholesterol 7alpha-hydroxylase (CYP7A1) mRNA level in the BP and BBP groups was significantly higher than that in the control group. The cecal total short-chain fatty acid concentrations in the BBP group were significantly higher than those in the control group. These results indicate that the observed changes in serum lipid levels in the BP and BBP groups were due to the increased fecal lipid and CYP7A1 mRNA levels.

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