(−)-Epigallocatechin-3-gallate Enhances Uncoupling Protein 2 Gene Expression in 3T3-L1 Adipocytes | Zendy

Mak-Soon Lee | Zendy; Yangha Kim | Zendy

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(−)-Epigallocatechin-3-gallate Enhances Uncoupling Protein 2 Gene Expression in 3T3-L1 Adipocytes

Author(s) -

Mak-Soon Lee,

Yangha Kim

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80563

Subject(s) - messenger rna , uncoupling protein , epigallocatechin gallate , 3t3 l1 , thermogenin , gene expression , chemistry , thermogenesis , microbiology and biotechnology , gene , transporter , biology , biochemistry , brown adipose tissue , adipose tissue , polyphenol , adipogenesis , antioxidant

In this study, we investigated the effects of green tea (-)-epigallocatechin-3-gallate (EGCG) on the mRNA level and promoter activity of uncoupling protein 2 (UCP2), a mitochondrial membrane transporter that regulates energy expenditure and thermogenesis in 3T3-L1 adipocytes. EGCG up-regulated the UCP2 mRNA level in a dose-dependent manner. UCP2 promoter activity was significantly stimulated by EGCG treatment, to an extent similar to that seen in mRNA expression. These results suggest that expression of UCP2 gene is directly regulated by green tea EGCG, which is mediated through the transcriptional activation of its proximal promoter.

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