Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs | Zendy

Yuuki Sato | Zendy; Hiroshi Kamiyama | Zendy; Takeo Usui | Zendy; Tamio Saito | Zendy; Hiroyuki Osada | Zendy; Shigefumi Kuwahara | Zendy; Hiromasa Kiyota | Zendy

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Synthesis and Anti-Angiogenic Activity of Cortistatin Analogs

Author(s) -

Yuuki Sato,

Hiroshi Kamiyama,

Takeo Usui,

Tamio Saito,

Hiroyuki Osada,

Shigefumi Kuwahara,

Hiromasa Kiyota

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80562

Subject(s) - isoquinoline , estrone , chemistry , stereochemistry , sponge , combinatorial chemistry , biochemistry , biology , hormone , botany

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

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