Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells | Zendy

Mario Soria | Zendy; Mónica A. Mechoud | Zendy; Angela MARTIN DE QUEVEDO | Zendy; Graciela Font de Valdez | Zendy; Ana V. Rodríguez | Zendy

Open Access

Disruption of Lipid Rafts Enhances the Effect of Lactobacilli on the Production of Tumor Necrosis Factor-Alpha in Mononuclear Blood Cells

Author(s) -

Mario Soria,

Mónica A. Mechoud,

Angela MARTIN DE QUEVEDO,

Graciela Font de Valdez,

Ana V. Rodríguez

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80445

Subject(s) - lipid raft , peripheral blood mononuclear cell , tumor necrosis factor alpha , cytokine , microbiology and biotechnology , alpha (finance) , biology , chemistry , immunology , medicine , biochemistry , signal transduction , in vitro , construct validity , nursing , patient satisfaction

We investigated, to determine whether disruption of lipid rafts would influence the effect of three selected strains of Lactobacillus on TNF-alpha production by peripheral blood mononuclear cells. Two strains increased TNF-alpha production; and the third one reduced cytokine levels. Disruption of rafts changed the immunomodulatory effect of the three strains. This is the first report on a potential role of rafts in lactobacilli-cell interaction.

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