Oral Administration ofLactobacillus plantarumNRIC0380 Suppresses IgE Production and Induces CD4+CD25+Foxp3+Cellsin Vivo | Zendy

Mai Enomoto | Zendy; Sayo NOGUCHI | Zendy; Makoto Hattori | Zendy; Hisashi SUGIYAMA | Zendy; Yasuyuki Suzuki | Zendy; Akihiro Hanaoka | Zendy; Sanae Okada | Zendy; Tadashi Yoshida | Zendy

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Oral Administration ofLactobacillus plantarumNRIC0380 Suppresses IgE Production and Induces CD4⁺CD25⁺Foxp3⁺Cellsin Vivo

Author(s) -

Mai Enomoto,

Sayo NOGUCHI,

Makoto Hattori,

Hisashi SUGIYAMA,

Yasuyuki Suzuki,

Akihiro Hanaoka,

Sanae Okada,

Tadashi Yoshida

Publication year - 2009

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80438

Subject(s) - foxp3 , immunoglobulin e , lactobacillus plantarum , spleen , il 2 receptor , antigen , oral administration , microbiology and biotechnology , in vivo , chemistry , immunology , bacteria , biology , lactic acid , immune system , antibody , pharmacology , t cell , genetics

The influence of lactic acid bacteria (LAB) on CD4(+)Foxp3(+) cells has not been investigated, although it has been reported that CD4(+)Foxp3(+) cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4(+)Foxp3(+) generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4(+)CD25(+)Foxp3(+) cells in whole CD4(+) cells was significantly higher in both Peyer's patch and the spleen of mice that had been fed with LAB than in the control mice.

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