Indole-3-carbinol Suppresses Tumor-Induced Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis | Zendy

Kazuhiro Kunimasa | Zendy; Tomomi Kobayashi | Zendy; Sayuri Sugiyama | Zendy; Kazuhiko Kaji | Zendy; Toshiro Ohta | Zendy

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Indole-3-carbinol Suppresses Tumor-Induced Angiogenesis by Inhibiting Tube Formation and Inducing Apoptosis

Author(s) -

Kazuhiro Kunimasa,

Tomomi Kobayashi,

Sayuri Sugiyama,

Kazuhiko Kaji,

Toshiro Ohta

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80292

Subject(s) - angiogenesis , apoptosis , chemistry , in vivo , cancer research , indole test , mechanism (biology) , microbiology and biotechnology , biology , biochemistry , genetics , philosophy , epistemology

Indole-3-carbinol (I3C) has been reported to exert anticancer activity in vivo. However, its anticancer mechanism has not been fully elucidated. In this study, we demonstrate that I3C suppressed tumor-induced angiogenesis and tube formation of endothelial cells. I3C also induced apoptosis in endothelial cells by activating the caspase cascade. We propose that I3C exerts its anticancer effect through the induction of endothelial apoptosis.

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