Ansaetherone, a New Radical Scavenger fromStreptomycessp. | Zendy

Toshikazu Komoda | Zendy; Kazuaki Akasaka | Zendy; Akira Hirota | Zendy

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Ansaetherone, a New Radical Scavenger fromStreptomycessp.

Author(s) -

Toshikazu Komoda,

Kazuaki Akasaka,

Akira Hirota

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80282

Subject(s) - scavenger , moiety , strain (injury) , free radical scavenger , chemistry , streptomyces , sugar , scavenging , chemical structure , stereochemistry , hydroxyl radical , biochemistry , radical , organic chemistry , antioxidant , biology , bacteria , anatomy , genetics

We identified a new radical scavenger, ansaetherone (C26 H33 NO7), from a culture of the Streptomyces sp. USF-4727 strain. In our previous study, it was shown that this strain produced four lipoxygenase inhibitors, tetrapetalones A, B, C and D. The chemical structure of ansaetherone was elucidated by the spectroscopic method, indicating that this compound was constructed with an aglycon and a sugar moiety. This chemical structure suggested that ansaetherone was related to the tetrapetalones. This finding provided information regarding tetrapetalone biosynthesis. Ansaetherone showed radical scavenging activity with an ED50 value of 300 microM in our assay.

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