Determination of Branched β-Cyclodextrin–Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry | Zendy

Naoe Yamane | Zendy; Zenzaburo Tozuka | Zendy; Yasuyo Okada | Zendy; Chie Honda | Zendy; Y. Nishi | Zendy; Toshiko Tanimoto | Zendy

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Determination of Branched β-Cyclodextrin–Prostaglandin Complexes Using Electrospray Ionization Mass Spectrometry

Author(s) -

Naoe Yamane,

Zenzaburo Tozuka,

Yasuyo Okada,

Chie Honda,

Y. Nishi,

Toshiko Tanimoto

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80233

Subject(s) - chemistry , cyclodextrin , electrospray ionization , mass spectrometry , electrospray , inclusion compound , acetonitrile , chromatography , nuclear chemistry

Mass spectral measurements by electrospray ionization mass spectrometry (ESI-MS) detected the ions of beta-cyclodextrin (betaCD) or branched betaCDs (glucosyl-, galactosyl-, mannosyl- and maltosyl-betaCD)-prostaglandins (PGs: PGA(2), PGD(2), PGE(1), PGE(2), PGF(2alpha) and PGJ(2)) complexes, i.e., betaCD-PG complexes, with a host:guest ratio of 1:1 in the negative ion mode. This is the first study to report the ions of branched betaCD-PG complexes using ESI-MS. The inclusion complexes were determined by a flow injection analysis using acetonitrile/water. We could confirm by this method the presence of a betaCD-PGE(2) complex with a host:guest ratio of 1:1 in a solution-dissolved pharmaceutical formulation consisting of betaCD-PGE(2) (Prostarmon E tablet).

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