Dietary Phospholipid Concentrate from Bovine Milk Improves Epidermal Function in Hairless Mice | Zendy

Yuko Haruta | Zendy; Ken Kato | Zendy; Toshimitsu Yoshioka | Zendy

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Dietary Phospholipid Concentrate from Bovine Milk Improves Epidermal Function in Hairless Mice

Author(s) -

Yuko Haruta,

Ken Kato,

Toshimitsu Yoshioka

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80212

Subject(s) - stratum corneum , transepidermal water loss , hairless , epidermis (zoology) , phospholipid , chemistry , barrier function , zoology , endocrinology , medicine , biochemistry , biology , anatomy , pathology , microbiology and biotechnology , membrane

We investigated the effect of dietary phospholipid (PL) concentrate from bovine milk on the epidermis. Thirteen-week-old hairless male and female mice (Hos:HR-1) were separated into two experimental groups, each fed two experimental diets: the control group and the PL group. The mice were given the experimental diets for 6 weeks. Stratum corneum hydration and transepidermal water loss (TEWL) were measured using Corneometer CM825 and Tewameter TM300 (Courage and Khazaka Electronics, Cologne, Germany) at 3 weeks and 6 weeks. After the feeding period, ceramides in stratum corneum were analyzed. We found that stratum corneum hydration and ceramides in the PL group were significantly higher than those in the control group and that TEWL in the PL group tended to decrease. These results indicate that dietary PL concentrate improves epidermal function by increasing the amount of ceramides, resulting in higher hydration.

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