Propolis Suppresses Tumor Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells | Zendy

Toshiro Ohta | Zendy; Kazuhiro Kunimasa | Zendy; Tomomi Kobayashi | Zendy; Miwa Sakamoto | Zendy; Kazuhiko Kaji | Zendy

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Propolis Suppresses Tumor Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells

Author(s) -

Toshiro Ohta,

Kazuhiro Kunimasa,

Tomomi Kobayashi,

Miwa Sakamoto,

Kazuhiko Kaji

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80169

Subject(s) - propolis , angiogenesis , apoptosis , in vivo , in vitro , chemistry , microbiology and biotechnology , mechanism (biology) , cancer research , biology , biochemistry , genetics , physics , food science , quantum mechanics

We have reported that propolis suppresses tumor-induced angiogenesis in vivo and in vitro, but antiangiogenic mechanism of propolis at cellular level remains unclear. In this study, we observed that propolis not only inhibited tube formation but also induced apoptosis of endothelial cells. These results suggest that propolis exerts its antiangiogenic effects at least in part through induction of apoptosis.

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