Open AccessThe Yeast Checkpoint Kinase Dun1 DownregulatesDIN7in the Absence of DNA Damage
Author(s) -
Ayako Yoshitani,
Feng Ling,
Minoru Yoshida
Publication year - 2008
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.80114
Subject(s) - g2 m dna damage checkpoint , dna damage , checkpoint kinase 2 , chek1 , yeast , downregulation and upregulation , dna , microbiology and biotechnology , gene , psychological repression , dna repair , biology , cell cycle checkpoint , kinase , chemistry , gene expression , genetics , cell cycle
Yeast DIN7 is a DNA damage-inducible gene. Its expression is increased in the absence of Dun1, a DNA damage checkpoint kinase. We identified a DIN7 promoter region responsible for Dun1-mediated downregulation and found that DIN7 expression was not further increased in response to hydroxyurea in Deltadun1 cells. Thus DIN7 repression by Dun1 can be released upon DNA damage.
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