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Effects of Various Amino Acids on Methionine-Induced Hyperhomocysteinemia in Rats
Author(s) -
Shin-ichiro FUKADA,
Tatsuya Morita,
Kimio SUGIYAMA
Publication year - 2008
Publication title -
bioscience biotechnology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.509
H-Index - 116
eISSN - 1347-6947
pISSN - 0916-8451
DOI - 10.1271/bbb.70833
Subject(s) - methionine , amino acid , homocysteine , cystine , histidine , glycine , hyperhomocysteinemia , arginine , serine , chemistry , biochemistry , amino acid synthesis , cysteine , lysine , phosphorylation , enzyme
Rats were fed diets supplemented with 1% L-methionine with and without 2.5% various amino acids for 7 d to determine what amino acids other than glycine, serine, and cystine can suppress methionine-induced hyperhomocysteinemia. L-Glutamic acid, L-histidine, and L-arginine significantly suppressed methionine-induced enhancement of plasma homocysteine concentrations, but the mechanisms underlying the effect of these amino acids are thought not to be identical.

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