Effects of a Casein Hydrolysate Prepared fromAspergillus oryzaeProtease on Adjuvant Arthritis in Rats | Zendy

Michio HATORI | Zendy; Kohji Ohki | Zendy; Shinichi Hirano | Zendy; Xiaoping Yang | Zendy; Hiroshi Kuboki | Zendy; Chiyuki Abe | Zendy

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Effects of a Casein Hydrolysate Prepared fromAspergillus oryzaeProtease on Adjuvant Arthritis in Rats

Author(s) -

Michio HATORI,

Kohji Ohki,

Shinichi Hirano,

Xiaoping Yang,

Hiroshi Kuboki,

Chiyuki Abe

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70792

Subject(s) - adjuvant , rheumatoid arthritis , aspergillus oryzae , casein , nitric oxide , arthritis , medicine , protease , pharmacology , chemistry , biochemistry , enzyme

We evaluated the effects of a casein hydrolysate (CH) prepared from Aspergillus oryzae protease on rat adjuvant arthritis, a model of human rheumatoid arthritis. CH was administered orally once a day to the animals for 22 d after the adjuvant injection. CH suppressed swelling in the adjuvant-uninjected hind paws, and a higher dose of CH suppressed the increase in arthritic score and swelling of the adjuvant-injected hind paws. A histopathological examination revealed evidence that the higher dose of CH suppressed the articular changes in the rats. In addition, CH suppressed the production of nitric oxide and prostaglandin E(2) in the plasma of the rats. These results suggest that CH had a suppressive effect on adjuvant arthritis by inhibiting the acute and chronic inflammatory reactions.

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