Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayersviathe Paracellular Pathway | Zendy

Nozomi Hisada | Zendy; Hideo Satsu | Zendy; Akira Mori | Zendy; Mamoru Totsuka | Zendy; Jun-ichi Kamei | Zendy; Takashi Nozawa | Zendy; Makoto Shimizu | Zendy

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Low-Molecular-Weight Hyaluronan Permeates through Human Intestinal Caco-2 Cell Monolayersviathe Paracellular Pathway

Author(s) -

Nozomi Hisada,

Hideo Satsu,

Akira Mori,

Mamoru Totsuka,

Jun-ichi Kamei,

Takashi Nozawa,

Makoto Shimizu

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70748

Subject(s) - paracellular transport , caco 2 , permeability (electromagnetism) , monolayer , tight junction , chemistry , biophysics , intestinal permeability , cell , biochemistry , biology , membrane , immunology

The intestinal permeability of low-molecular-weight hyaluronan (LMW-HA) was investigated by using cultured monolayers of Caco-2 cells. The amount of LMW-HA that permeated the Caco-2 monolayers was measured by a carbazole assay. The permeability of LMW-HA increased inversely with the molecular size and was dose-dependent. The transport was observed to be energy-independent, and was correlated with the tight junction (TJ) permeability. These results suggest that LMW-HA permeated the Caco-2 cell monolayers via the paracellular pathway.

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