Distribution ofL-Azetidine-2-carboxylateN-Acetyltransferase in Yeast | Zendy

Masaru Wada | Zendy; Kae OKABE | Zendy; Michihiko Kataoka | Zendy; Sakayu Shimizu | Zendy; Atsushi Yokota | Zendy; Hiroshi Takagi | Zendy

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Distribution ofL-Azetidine-2-carboxylateN-Acetyltransferase in Yeast

Author(s) -

Masaru Wada,

Kae OKABE,

Michihiko Kataoka,

Sakayu Shimizu,

Atsushi Yokota,

Hiroshi Takagi

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70534

Subject(s) - acetyltransferase , saccharomyces cerevisiae , yeast , biochemistry , chemistry , acetyltransferases , microbiology and biotechnology , gene , biology , acetylation

The budding yeast Saccharomyces cerevisiae Sigma1278b contains the MPR1 gene encoding N-acetyltransferase, which detoxifies the L-proline analog L-azetidine-2-carboxylate (AZC). Of 131 yeasts tested, AZC acetyltransferase activity was detected in 17 strains of 41 strains that showed AZC resistance. Degenerate-PCR analysis revealed that two strains, i.e., Candida saitoana AKU4533 and Wickerhamia fluorescens AKU4722, contained a DNA fragment highly homologous to MPR1. This indicates that AZC acetyltransferases are widely distributed in yeasts.

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