Excess Leucine Intake Induces Serine Dehydratase in Rat Liver | Zendy

Bo Zhong | Zendy; Shunsuke Sakai | Zendy; Tohru SAEKI | Zendy; Ryuhei Kanamoto | Zendy

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Excess Leucine Intake Induces Serine Dehydratase in Rat Liver

Author(s) -

Bo Zhong,

Shunsuke Sakai,

Tohru SAEKI,

Ryuhei Kanamoto

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70512

Subject(s) - valine , leucine , serine , medicine , isoleucine , dehydratase , endocrinology , amino acid , chemistry , biology , alanine , biochemistry , enzyme

We have hypothesized that rat liver serine dehydratase (SDH) is induced in response to the amount of surplus amino acids from dietary protein. In the present study, we found that excess leucine intake strongly induced SDH activity in the liver but not in the kidney of rats. The increase in activity was accompanied by increases in the levels of SDH mRNA. On the other hand, isoleucine and valine had little effect on SDH induction. These results support our hypothesis and suggest that leucine is a signal for SDH induction.

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