Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency | Zendy

Norihiro Mutoh | Zendy; Satoko Kitajima | Zendy

Open Access

Accelerated Chronological Aging of a Mutant Fission Yeast Deficient in Both Glutathione and Superoxide Dismutase Having Cu and Zn as Cofactors and Its Enhancement by Sir2 Deficiency

Author(s) -

Norihiro Mutoh,

Satoko Kitajima

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70307

Subject(s) - schizosaccharomyces pombe , superoxide dismutase , cofactor , menadione , mutant , biochemistry , glutathione , yeast , dismutase , chemistry , superoxide , biology , oxidative stress , gene , enzyme

A mutant of Schizosaccharomyces pombe deficient in both superoxide dismutase with copper and zinc as cofactors and glutathione was hypersensitive to menadione, which intracellularly generates superoxide radicals, and showed short chronological lifespan with more oxidation of proteins. Disruption of the sir2 gene in the double mutant enhanced the short chronological lifespan without more enhanced protein oxidation.

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