Juvenile Hormone Activity of Ethyl 4-(2-Aryloxyhexyloxy)benzoates with Precocious Metamorphosis-Inducing Activity | Zendy

Norihiro Fujita | Zendy; Kiyo Ashibe | Zendy; Naotaka Yamada | Zendy; Takahiro Shiotsuki | Zendy; Makoto Kiuchi | Zendy; Eiichi Kuwano | Zendy

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Juvenile Hormone Activity of Ethyl 4-(2-Aryloxyhexyloxy)benzoates with Precocious Metamorphosis-Inducing Activity

Author(s) -

Norihiro Fujita,

Kiyo Ashibe,

Naotaka Yamada,

Takahiro Shiotsuki,

Makoto Kiuchi,

Eiichi Kuwano

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70265

Subject(s) - metamorphosis , juvenile hormone , estradiol benzoate , benzoates , endocrinology , medicine , bombyx mori , instar , larva , methoprene , ethyl benzoate , chemistry , hormone , biology , biochemistry , organic chemistry , ecology , ovariectomized rat , gene , catalysis

Ethyl 4-[2-(6-methyl-3-pyridyloxy)hexyloxy]benzoate (1) and ethyl 4-(2-phenoxyhexyloxy)benzoate (2), which induce precocious metamorphosis in larvae of Bombyx mori, a clear sign of juvenile hormone (JH) deficiency, showed JH activity when topically applied to allatectomized 4th instar larvae of B. mori. Compounds 1 and 2 induced precocious metamorphosis with doses at which they were effective as JH agonists.

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