Inhibition of 17α-Hydroxylase/C17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins | Zendy

Kenichi Kimura | Zendy; Yoshie Itakura | Zendy; Reika GOTO | Zendy; Masato Tojima | Zendy; Nobumi EGAWA | Zendy; Makoto Yoshihama | Zendy

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Inhibition of 17α-Hydroxylase/C_17,20-Lyase (CYP17) from Rat Testis by Green Tea Catechins and Black Tea Theaflavins

Author(s) -

Kenichi Kimura,

Yoshie Itakura,

Reika GOTO,

Masato Tojima,

Nobumi EGAWA,

Makoto Yoshihama

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70258

Subject(s) - theaflavin , catechin , gallate , chemistry , lncap , black tea , cytotoxicity , ic50 , epigallocatechin gallate , biochemistry , green tea , food science , in vitro , polyphenol , cancer cell , biology , cancer , antioxidant , nuclear chemistry , genetics

In the course of screening for 17alpha-hydroxylase/C17,20-lyase inhibitors from food ingredients, the methanol soluble fraction of green tea and black tea, which were expected to be rich in catechin and theaflavin content, showed potent inhibitory activity. (-)-Epigallocathechin gallate and theaflavin 3-O-gallate with a pirogallol moiety significantly inhibited C17,20-lyase activity on IC50 values of 24.5 microM and 11.5 microM respectively. They had potent cytotoxicity against human prostate cancer LNCaP cells (IC50=28.1 microM and 37.4 microM).

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