Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells | Zendy

Hoon-Seok Yoon | Zendy; Sun-Ryung Lee | Zendy; HeeChul Ko | Zendy; SooYoun Choi | Zendy; JiGweon Park | Zendy; JeongKook Kim | Zendy; SeJae Kim | Zendy

Open Access

Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells

Author(s) -

Hoon-Seok Yoon,

Sun-Ryung Lee,

HeeChul Ko,

SooYoun Choi,

JiGweon Park,

JeongKook Kim,

SeJae Kim

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70088

Subject(s) - nobiletin , melanin , mapk/erk pathway , extracellular , melanoma , tyrosinase , kinase , chemistry , microphthalmia associated transcription factor , signal transduction , microbiology and biotechnology , cancer research , biochemistry , biology , enzyme , antioxidant , flavonoid

Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.

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