Enzymatic Synthesis of β-Lactam Antibiotics andN-Fatty-Acylated Amino Compounds by the Acyl-Transfer Reaction Catalyzed by Penicillin V Acylase fromStreptomyces mobaraensis | Zendy

Mayuko Koreishi | Zendy; Kazuha TANI | Zendy; Yuuichi ISE | Zendy; Hiroyuki Imanaka | Zendy; Koreyoshi Imamura | Zendy; Kazuhiro Nakanishi | Zendy

Open Access

Enzymatic Synthesis of β-Lactam Antibiotics andN-Fatty-Acylated Amino Compounds by the Acyl-Transfer Reaction Catalyzed by Penicillin V Acylase fromStreptomyces mobaraensis

Author(s) -

Mayuko Koreishi,

Kazuha TANI,

Yuuichi ISE,

Hiroyuki Imanaka,

Koreyoshi Imamura,

Kazuhiro Nakanishi

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70052

Subject(s) - chemistry , penicillin amidase , acylation , acyl group , nucleophile , nucleophilic acyl substitution , enzyme , penicillin , catalysis , antibiotics , substrate (aquarium) , fatty acid , lactam , stereochemistry , amino acid , organic chemistry , biochemistry , biology , ecology , alkyl

Penicillin V acylase from Streptomyces mobaraensis (Sm-PVA) showed high acyl-transfer activity in reactions using methyl esters of carboxylic acid (acyl donor) and amino compounds (nucleophile), to produce the corresponding amides. Moreover, Sm-PVA had broad substrate specificity, as indicated by the fact that it catalyzed the efficient synthesis of beta-lactam antibiotics, capsaicin derivatives, and N-fatty-acyl-amino acid/N-fatty-acyl-peptide derivatives.

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