Effects of a Hop Water Extract on the Compound 48/80-Stimulated Vascular Permeability in ICR Mice and Histamine Release from OVA-Sensitized BALB/c Mice | Zendy

Shuichi Segawa | Zendy; Yoshihiro TAKATA | Zendy; Hirotaka Kaneda | Zendy; Junji Watari | Zendy

Open Access

Effects of a Hop Water Extract on the Compound 48/80-Stimulated Vascular Permeability in ICR Mice and Histamine Release from OVA-Sensitized BALB/c Mice

Author(s) -

Shuichi Segawa,

Yoshihiro TAKATA,

Hirotaka Kaneda,

Junji Watari

Publication year - 2007

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70047

Subject(s) - histamine , ovalbumin , chemistry , evans blue , pharmacology , immunoglobulin e , stimulation , vascular permeability , balb/c , compound 48/80 , immunology , antigen , endocrinology , antibody , biochemistry , medicine , receptor , degranulation , immune system

The antiallergic properties of a hop water extract (HWE) were studied by evaluating the Evans blue leakage from ICR mice caused by compound 48/80 stimulation, and the histamine release from ovalbumin (OVA)-sensitized BALB/c mice. An oral administration of HWE significantly inhibited the vascular permeability and histamine release. HWE itself did not have any influence on the total and antigen-specific immunoglobulin E (IgE) production in OVA-sensitized mice. These results indicate that HWE exerted an antiallergic effect by inhibiting the release of chemical mediators from mast cells and basophiles.

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