The Region in a Subunit of theAspergillusCCAAT-Binding Protein Similar to the HAP4p-Recruiting Domain ofSaccharomyces cerevisiaeHap5p Is Not Essential for Transcriptional Enhancement | Zendy

Shinjiro Tanoue | Zendy; Ken-ichi Kamei | Zendy; Hideya Goda | Zendy; Akimitsu Tanaka | Zendy; Tetsuo Kobayashi | Zendy; Norihiro Tsukagoshi | Zendy; Masashi Kato | Zendy

Open Access

The Region in a Subunit of theAspergillusCCAAT-Binding Protein Similar to the HAP4p-Recruiting Domain ofSaccharomyces cerevisiaeHap5p Is Not Essential for Transcriptional Enhancement

Author(s) -

Shinjiro Tanoue,

Ken-ichi Kamei,

Hideya Goda,

Akimitsu Tanaka,

Tetsuo Kobayashi,

Norihiro Tsukagoshi,

Masashi Kato

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70.782

Subject(s) - protein subunit , saccharomyces cerevisiae , gene , aspergillus oryzae , conserved sequence , domain (mathematical analysis) , biology , genetics , protein domain , fungal protein , peptide sequence , biochemistry , enzyme , mathematical analysis , mathematics

The CCAAT-binding complex in Aspergillus species, known as the Hap complex, consists of at least three subunits, HapB, HapC, and HapE. Each Hap subunit contains an evolutionarily conserved core domain. In this study, a series of the truncated gene, which encodes the HapE subunit of Aspergillus oryzae, was constructed to survey the regions essential for the transcriptional enhancement of fungal genes. It was revealed that the non-conserved regions and the conserved region similar to the Hap4p recruiting domain of Saccharomyces cerevisiae were not necessary for Hap complex-mediated transcriptional enhancement.

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