Antiproliferative Activity of Root Extract from Gentian Plant (Gentiana triflora) on Cultured and Implanted Tumor Cells | Zendy

Kazushige Matsukawa | Zendy; Mika Ogata | Zendy; Takashi Hikage | Zendy; Hiroyuki Minami | Zendy; Yoshitaka Shimotai | Zendy; Yasushi Saitoh | Zendy; Tetsuro Yamashita | Zendy; Atsushi Ouchi | Zendy; Reiko Tsutsumi | Zendy; Tomoaki Fujioka | Zendy; Kenichi Tsutsumi | Zendy

Open Access

Antiproliferative Activity of Root Extract from Gentian Plant (Gentiana triflora) on Cultured and Implanted Tumor Cells

Author(s) -

Kazushige Matsukawa,

Mika Ogata,

Takashi Hikage,

Hiroyuki Minami,

Yoshitaka Shimotai,

Yasushi Saitoh,

Tetsuro Yamashita,

Atsushi Ouchi,

Reiko Tsutsumi,

Tomoaki Fujioka,

Kenichi Tsutsumi

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70.1046

Subject(s) - gentiana , apoptosis , dna fragmentation , programmed cell death , fragmentation (computing) , cell culture , growth inhibition , biology , dna , chemistry , botany , pharmacology , microbiology and biotechnology , traditional medicine , biochemistry , medicine , genetics , ecology

We describe a novel pharmacological activity of the gentian root, an ingredient of Chinese medicines. Root extract from Gentiana triflora triggered cell death of human Daudi cells in culture. In addition, daily administration of the extract to mice inhibited growth of implanted solid tumors. Extract treatment of cultured cells resulted in the appearance of shranken, fragmented, or condensed cell and nuclear morphologies, and in chromosomal DNA degradation. But, the extract-treated cells did not show DNA fragmentation, which exhibits a nucleosome ladder, suggesting that extract-triggered cell death is not mediated through a typical apoptotic pathway.

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