Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-b]furan-4,9-diones and Their Related Compounds | Zendy

Masayuki Ogawa | Zendy; Jyunichi Koyanagi | Zendy; Aiko Sugaya | Zendy; Tadashi Tsuda | Zendy; Hiromi Ohguchi | Zendy; Kouji Nakayama | Zendy; Katsumi Yamamoto | Zendy; Akira Tanaka | Zendy

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Cytotoxic Activity toward KB Cells of 2-Substituted Naphtho[2,3-b]furan-4,9-diones and Their Related Compounds

Author(s) -

Masayuki Ogawa,

Jyunichi Koyanagi,

Aiko Sugaya,

Tadashi Tsuda,

Hiromi Ohguchi,

Kouji Nakayama,

Katsumi Yamamoto,

Akira Tanaka

Publication year - 2006

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.70.1009

Subject(s) - furan , cytotoxicity , cytotoxic t cell , chemistry , stereochemistry , organic chemistry , biochemistry , in vitro

We investigated the cytotoxic activity of 2-substituted naphtho[2,3-b]furan-4,9-diones. We have previously synthesized 33 types of 2-substituted and related compounds, and the cytotoxic activity of these compounds was then examined by a KB cell culture assay. 2-(3-Furanoyl)benzoic acids and 1,4-naphthoquinones had no activity. 2-Acetyl-4,9-dimethoxynaphtho[2,3-b]furan 4 showed low activity. However, parent naphtho[2,3-b]furan-4,9-dione 2 and most 2-substituted derivatives exhibited cytotoxic activity. The parent structure was therefore for cytotoxicity. 2-Formylnaphtho[2,3-b]furan-4,9-dione 11 had particularly potent activity (ED50=0.09 microg/ml).

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