Biosynthetic Origin of the Carbon Skeleton and Nitrogen Atom of Pamamycin-607, a Nitrogen-Containing Polyketide | Zendy

Makoto Hashimoto | Zendy; Haruhiko KOMATSU | Zendy; Ikuko Kozone | Zendy; Hiroshi Kawaide | Zendy; Hiroshi Abe | Zendy; Masahiro Natsume | Zendy

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Biosynthetic Origin of the Carbon Skeleton and Nitrogen Atom of Pamamycin-607, a Nitrogen-Containing Polyketide

Author(s) -

Makoto Hashimoto,

Haruhiko KOMATSU,

Ikuko Kozone,

Hiroshi Kawaide,

Hiroshi Abe,

Masahiro Natsume

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.315

Subject(s) - propionate , nitrogen , nitrogen atom , chemistry , polyketide , biosynthesis , carbon fibers , carbon skeleton , stereochemistry , amino acid , carbon atom , organic chemistry , biochemistry , group (periodic table) , ring (chemistry) , enzyme , materials science , composite number , composite material

The biosynthesis of pamamycin-607 (PM-607), a sixteen-membered macrodiolide compound, was studied with 13C- and 15N-labeled precursor units in Streptomyces alboniger. Feeding experiments with 13C-labeled acetate or propionate indicate that the carbon skeleton of PM-607 was derived from six acetate, four propionate and three succinate units. MS analyses of 15N-labeled PM-607 suggest that the nitrogen atom in PM-607 was derived from the alpha-amino group of an amino acid.

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