Oral Administration of Freeze-Dried Kefir Reduces Intestinal Permeation of and Oral Sensitization to Ovalbumin in Mice | Zendy

Chisato Umeda | Zendy; Kei Sonoyama | Zendy; Natsu Yamaguchi | Zendy; Ryo� Saito | Zendy; Keiko Akashi | Zendy; Hidemasa Motoshima | Zendy; Jun Kawabata | Zendy

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Oral Administration of Freeze-Dried Kefir Reduces Intestinal Permeation of and Oral Sensitization to Ovalbumin in Mice

Author(s) -

Chisato Umeda,

Kei Sonoyama,

Natsu Yamaguchi,

Ryo� Saito,

Keiko Akashi,

Hidemasa Motoshima,

Jun Kawabata

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.249

Subject(s) - ovalbumin , sensitization , oral administration , chemistry , kefir , immunology , antigen , pharmacology , medicine , biology , lactic acid , bacteria , genetics

An increase in plasma ovalbumin concentrations after intragastric administration of ovalbumin was suppressed by concomitant freeze-dried kefir in BALB/c mice. Serum levels of ovalbumin-specific immunoglobulin G and proliferation of splenic mononuclear cells in mice immunized orally with ovalbumin were suppressed by feeding freeze-dried kefir. We propose that kefir reduces intestinal permeation of food antigen, which contributes to suppression of oral sensitization.

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