Interaction of Modified Cyclodextrins with Cytochrome P-450 | Zendy

Minoru Ishikawa | Zendy; Hidefumi Yoshii | Zendy; Takeshi Furuta | Zendy

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Interaction of Modified Cyclodextrins with Cytochrome P-450

Author(s) -

Minoru Ishikawa,

Hidefumi Yoshii,

Takeshi Furuta

Publication year - 2005

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.69.246

Subject(s) - cyp1a2 , cyp3a4 , cyp2c9 , chemistry , cytochrome p450 , cyp2c19 , cytochrome , cyp2d6 , in vitro , complementary dna , biochemistry , microbiology and biotechnology , stereochemistry , enzyme , biology , gene

The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4). The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations. In addition, methyl-beta-CD inhibited CYP1A2 and CYP2D6 at higher concentrations.

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